`Nodular necrobiosis': a new cutaneous manifestation of Crohn's disease?

'Nodular necrobiosis': a new cutaneous manifestation of Crohn's disease?

A skin lesion previously unassociated with Crohn's disease is described. Although superficially resembling erythema nodosum it runs a different clinical course and has different histological appearances, the central feature being necrobiotic collagen. The term ;nodular necrobiosis' is suggested.

Primary Cutaneous Nodular Amyloidosis: A Rare Disease

© 2017 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow A 40‐year‐old male presented with a 6‐month history of a gradually progressing, painless, firm, 10 × 8 mm erythematous nodule on his nose [Figure 1]. Skin biopsy showed nodular deposition of eosinophilic, acellular, amyloid material in the entire dermis, which was surrounded by focal plasma cell infiltrate [Figure 2]...

Nodular necrobiosis in association with ulcerative colitis.

1 Ferguson A, Ziegler K. Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis. Gut 1986; 27: 675-9. 2 Niazi NM, Leigh RJ, Crowe P, Marsh MN. Morphometric analysis of small intestinal mucosa. I Methodology, epithelial volume compartments and enumeration of inter-epithelial space lymphocytes. Virchows Archiv [Pathol Ana...

Cutaneous manifestation of internal disease.

A brief account of the pathology and pathogenesis of the cutaneous manifestations of Crohns disease

Inflammatory Bowel Disease (IBD) is a lifelong condition, which may occur in patients of any age. Prior to confirming a diagnosis of IBD, clinicians may face unusual non gastrointestinal symptoms. The extra intestinal manifestations of Crohn's disease (CD) may develop prior to signs of gastrointestinal involvement. Many of these extraintestinal clinical signs overlap with those seen in patients...